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HERO ID
7104270
Reference Type
Journal Article
Title
Isoflurane hepatotoxicity in a patient with a previous history of halothane-induced hepatitis
Author(s)
Hasan, F; ,
Year
1998
Is Peer Reviewed?
Yes
Journal
Hepato-Gastroenterology
ISSN:
0172-6390
Publisher
H G E UPDATE MEDICAL PUBL LTD.
Location
ATHENS
Volume
45
Issue
20
Page Numbers
518-522
Language
English
PMID
9638441
Web of Science Id
WOS:000073153900047
Abstract
Halogenated volatile anesthetics have been associated with liver injury. Most reported cases have been linked to halothane and enflurane. Cross-sensitization between the latter agents has also been documented. Isoflurane hepatitis is extremely rare, and only a few convincing cases have been published. Moreover, clinical cases of cross-sensitization of isoflurane with other haloalkanes have not been reported. We describe a case of hepatic dysfunction 2 weeks after isoflurane anesthesia in a 35-year-old obese woman with a previous history of halothane hepatitis. The diagnosis was made on the basis of exposure to isoflurane, the delay between the time of exposure and the onset of jaundice, sind the exclusion of other causes of liver dysfunction. This case reiterates the recommendation that patients who sustain liver injury from one haloalkane should not be exposed to another.
Keywords
isoflurane; halothane hepatitis
Tags
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PFAS Universe
Data Source
Web of Science
Pubmed
Enflurane
Isoflurane
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