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7110760 
Journal Article 
EFFECT OF FISH OIL ON THE FATTY-ACID COMPOSITION OF HUMAN-MILK AND MATERNAL AND INFANT ERYTHROCYTES 
Henderson, RA; Jensen, RG; Lammikeefe, CJ; Ferris, AM; Dardick, KR; , 
1992 
AMER OIL CHEMISTS SOC 
CHAMPAIGN 
863-869 
1491604 
WOS:A1992JZ52800008 
To examine the effect of fish oil supplementation on the fatty acid (FA) composition of human milk and maternal and infant erythrocytes, five lactating women were supplemented with 6 g of fish oil daily for 21 d. Usual maternal diets contained 1,147 mg of total n-3 FA, with 120 mg from very long-chain (>C18) n-3 FA. Supplementation increased dietary levels to 3,092 mg of total n-3 FA and 2,006 mg of very long-chain n-3 FA. Milk samples were collected daily, prior to fish oil ingestion, and at 4-h intervals on days 1, 7, 14 and 21. Milk n-3 FA content increased within 8 h and reached steady state levels within one week. The n-6 fatty acid content decreased. Erythrocyte eicosapentaenoic acid content increased from 0.24% to 1.4% (P < 0.01) in mothers and from 0.11% to 0.70% (P < 0.05) in infants. Docosapentaenoic acid increased from 1.4% to 2.2% (P < 0.05) in mothers and from 0.30% to 0.78% (P < 0.01) in infants. There was no significant change in docosahexaenoic acid or n-6 fatty acid content. Maternal platelet aggregation responses were variable. No differences in milk or plasma tocopherol levels were noted. 
SYMP ON MILK LIPIDS, AT THE 1990 ANNUAL MEETING OF THE AMERICAN OIL CHEMISTS SOC 
BALTIMORE, MD