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7112779 
Journal Article 
Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan Analysis of the Iwaki Health Promotion Project 
Rajasekaran, SV; Achary, SN; Kimura, Y; Kurauchi, S; Nakaji, S; Okumura, Ken; Tomita, H; Yamada, M; Hanada, K; Endo, T; Narita, N; Narita, M; Senoo, M; Yonekura, M; Ichikawa, H; , 
2018 
Yes 
International Heart Journal
ISSN: 1349-2365 
INT HEART JOURNAL ASSOC 
TOKYO 
59 
4 
736-740 
English 
29877307 
WOS:000440870400012 
We previously showed that J-waves were found more frequently in patients with low levels of serum eicosapentaenoic acid (EPA) in the acute phase of myocardial infarction, and were associated with the incidence of ischemia-related ventricular arrhythmias. However, the relationship between J-waves and serum EPA levels in a general population remains to be elucidated.The Iwaki Health Promotion Project is an ongoing community-based health promotion study in Iwaki, Hirosaki, which is in northern Japan. A total of 1,052 residents (mean age, 53.9 +/- 15.4 years; 390 men) who participated in this project in 2014 were studied. A standard 12-lead electrocardiogram (ECG) was recorded and serum EPA levels were measured to evaluate the relationship between J-waves and serum EPA levels. J-waves were found in 52 (5%) subjects and were observed more frequently in male than female subjects (44 [11%] versus 8 [1%], P < 0.0001). More than half of the J-waves were the notched type (60%), and J-waves were detected most frequently in inferior leads on ECG (52%). The RR interval was longer and QTc duration shorter in subjects with J-waves than those without. No significant difference was found in serum EPA levels between subjects with and without J-waves (70 [49-116] versus 65 [41-106] mu g/mL, P = 0.40). In multivariate analysis. male gender and RR interval were independent factors associated with the presence of J-waves.There was no significant relationship between J-waves and serum EPA levels in this general population in Japan. Various mechanisms for manifestation of the J-waves are suggested.