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7119516 
Journal Article 
Abstract 
Lead aggravates the diabetic-induced neurodegeneration and neuro-protecting effect of C. carandas 
Kumar, A; Singh, R; Sharma, B 
2019 
Yes 
Journal of Neurochemistry
ISSN: 0022-3042
EISSN: 1471-4159 
150 
Suppl. 1 
130 
English 
WOS:000478639800309 
Diabetes, an unresolved metabolic disorder and lead contamination are prevalent problems in contemporary society. Previously, reported suggest that either diabetes or lead exposure resulted in neurodegeneration in male rats. The aim of this study was to evaluate whether diabetic rats exposed to lead demonstrate a higher degree of neurotoxicity, inflammation and neurodegeneration when compared with lead-exposed control rats. And the neuroprotective, anti-inflammatory and antioxidant activity of C. carandas constituents were also evaluated. Diabetes was induced by injecting a single dose of streptozotocin (40 mg/kg body weight). Control and diabetic rats were exposed to lead through oral gavage for a period of 21 days and assessed for neuro-inflammatory markers and oxidative endpoints. Significant reduction in brain antioxidant enzyme activity, membrane proteins and ion channels including Acetylcholinesterase, Na+-K+ ATPase levels and glutathione levels were observed in diabetic rats with an elevation in levels of superoxide anions, hydrogen peroxides, lipid peroxidation. Mild histopathological malformations were observed in the brain of the diabetic rats. TNF-α, IL-6 transcripts and nuclear factor-κB expression were increased in the diabetic rat brain. Similar oxidative and neurotoxicity was observed in lead-exposed control rats. Further, lead-exposed diabetic rats showed additional deterioration in hippocampal and inflammation end points and noteworthy elevation in oxidative toxicity suggesting that treatment with lead exacerbates neurotoxicity in streptozotocin-induced diabetic rats. The ameliorative efficacy of the aqueous extract of C. Carandas was analysed in diabetic rat exposed to lead. The study shows the significant neuroprotective and anti-inflammatory activity of the extract. 
Joint Meeting of the International-Society-for-Neurochemistry and American-Society-for-Neurochemistry (ISN-ASN) 
Montreal, Canada 
August 4-8, 2019