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7132842 
Journal Article 
Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract: neutrophilic host response, sustained infection, and clinical sequelae 
Stevens, JS; Criss, AK; , 
2018 
0 
Current Opinion in Hematology
ISSN: 1065-6251
EISSN: 1531-7048 
LIPPINCOTT WILLIAMS & WILKINS 
PHILADELPHIA 
13-21 
English 
29016383 
WOS:000428723000004 
Gonorrhea is a major global health concern, caused by the bacterium Neisseria gonorrhoeae. The main clinical feature of acute gonorrhea is neutrophilic influx that is unable to clear infection. Women of reproductive age are predominantly at risk for serious sequelae of gonorrhea, including pelvic inflammatory disease, ectopic pregnancy, and infertility. This review will highlight how neutrophils are recruited to the female reproductive tract (FRT) in response to N. gonorrhoeae, how N. gonorrhoeae resists killing by neutrophils, and the connection between neutrophilic inflammation and cellular damage.