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7133696 
Journal Article 
Treatment modalities and outcomes of Fanconi anemia patients with head and neck squamous cell carcinoma: Series of 9 cases and review of the literature 
Beckham, TH; Leeman, J; Tsai, CJ; Riaz, N; Sherman, E; Singh, B; Lee, N; Mcbride, S; Higginson, DS; , 
2019 
1 
Head & Neck
ISSN: 1043-3074
EISSN: 1097-0347 
WILEY 
HOBOKEN 
1418-1426 
30633423 
WOS:000466490000040 
Background Fanconi anemia (FA) is associated with an increased risk of developing head and neck squamous cell cancer (HNSCC) and presents a treatment dilemma due to concerns of increased toxicities from chemotherapy and radiation therapy (RT). Methods We reviewed the literature on HNSCC in FA patients and report on our experience treating 9 FA patients with HNSCC. Results Surgery was generally well-tolerated and surgery alone resulted in durable local control for 2 patients. Four patients received adjuvant RT that was tolerable in most cases, although 1 patient required a treatment break and early cessation of RT. Three of the irradiated patients received concurrent cetuximab. Conclusions In patients with adverse features, adjuvant radiation with concurrent cetuximab may be feasible with careful monitoring, although local disease control is infrequent. Early detection via screening permitting a surgery-alone approach represents the best opportunity for cure in FA patients with HSNCC.