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7135988 
Journal Article 
Talin and Kindlin as Integrin-Activating Proteins: Focus on the Heart 
Chen, C; Manso, AM; Ross, RS; , 
2019 
1 
Pediatric Cardiology
ISSN: 0172-0643
EISSN: 1432-1971 
SPRINGER 
NEW YORK 
1401-1409 
English 
31367953 
WOS:000509372900007 
Integrin receptors enable cells to sense and respond to their chemical and physical environment. As a class of membrane receptors, they provide a dynamic, tightly regulated link between the extracellular matrix or cellular counter-receptors and intracellular cytoskeletal and signaling networks. They enable transmission of mechanical force across the plasma membrane, and particularly for cardiomyocytes, may sense the mechanical load placed on cells. Talins and Kindlins are two families of FERM-domain proteins which bind the cytoplasmic tail of integrins, recruit cytoskeletal and signaling proteins involved in mechano-transduction, and those which synergize to activate integrins, allowing the integrins to physically change and bind to extracellular ligands. In this review, we will discuss the roles of talin and kindlin, particularly as integrin activators, with a focus on cardiac myocytes.