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Citation
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HERO ID
7136370
Reference Type
Journal Article
Title
DNA methylation in plants: mechanisms and tools for targeted manipulation
Author(s)
Gallego-Bartolomé, J; ,
Year
2020
Is Peer Reviewed?
1
Journal
New Phytologist
ISSN:
0028-646X
EISSN:
1469-8137
Language
English
PMID
32159848
DOI
10.1111/nph.16529
Abstract
DNA methylation is an epigenetic mark that regulates multiple processes, such as gene expression and genome stability. Mutants and pharmacological treatments have been instrumental in the study of this mark in plants, although their genome-wide effect complicates the direct association between changes in methylation and a particular phenotype. A variety of tools that allow locus-specific manipulation of DNA methylation can be used to assess its direct role in specific processes, as well as to create novel epialleles. Recently, new tools that recruit the methylation machinery directly to target loci through programmable DNA-binding proteins have expanded the tool kit available to researchers. This review provides an overview of DNA methylation in plants and discusses the tools that have recently been developed for its manipulation.
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