Further studies on the potent positive chronotropic effect of (15S)-15-methyl-prostaglandin E1 on the guinea-pig isolated spontaneously beating right atrium | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7140104

Reference Type

Journal Article

Title

Further studies on the potent positive chronotropic effect of (15S)-15-methyl-prostaglandin E1 on the guinea-pig isolated spontaneously beating right atrium

Author(s)

Serdar Soydan, A; Ugur, M; Yazar, O; Türker, RK; ,

Year

1992

Is Peer Reviewed?

Yes

Journal

General Pharmacology
ISSN: 0306-3623
EISSN: 1879-0011

Publisher

ELSEVIER SCIENCE INC

Location

NEW YORK

Page Numbers

187-191

Language

English

PMID

1322336

DOI

10.1016/0306-3623(92)90007-7

Web of Science Id

WOS:A1992HF71500007

Abstract

1. 15-Me-PGE1 (10(-14)-10(-11) M) elicited a concentration-dependent and long-lasting increase in heart rate without an effect on contractility of the isolated spontaneously beating guinea-pig right atria. 2. Noradrenaline, histamine and PGE1 produced a concentration-dependent increase in both heart rate and contractility with relatively higher concentrations. 3. beta-Adrenoceptor blocker propranolol and histamine H2-receptor blocker cimetidine inhibited the effects of noradrenaline and histamine respectively without altering the positive chronotropic effect of 15-Me-PGE1. 4. Prazosin and lidocaine partially inhibited the effect of 15-Me-PGE1, while reducing Na+ concentration in the medium to 50 mM almost completely inhibited the positive chronotropic effect of the analog. 5. Calcium channel blocker, nicardipine, decreased the positive chronotropic effect of 15-Me-PGE1 in a concentration-dependent manner. 6. These results were taken as an evidence for the specific and unique effect of 15-Me-PGE1 in the guinea-pig sinoatrial node interacting with Na+ and Ca2+ fluxes probably through their specific exchangers.