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7142366 
Journal Article 
Keratin pearl degradation in oral squamous cell carcinoma: reciprocal roles of neutrophils and macrophages 
Essa, AA; Yamazaki, M; Maruyama, S; Abé, T; Babkair, H; Cheng, J; Saku, T; , 
2014 
Yes 
Journal of Oral Pathology and Medicine
ISSN: 1600-0714
EISSN: 16000714 
WILEY-BLACKWELL 
HOBOKEN 
778-784 
English 
24931829 
WOS:000344543000009 
We have reported that neutrophilic infiltration was associated with round-shaped dyskeratosis foci, a kind of keratin pearl, of oral carcinoma in situ and that those inflammatory cells are recruited from intra-epithelially entrapped blood vessels. Based on these lines of evidence, we have formulated a hypothesis that keratin pearls are terminally degraded by neutrophils. To confirm this hypothesis, we investigated immunohistochemically stepwise degradation of keratin pearls in oral squamous cell carcinoma (SCC) to clarify any other type scavenger cells in addition to neutrophils are involved in this particular degradation process.