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7144935 
Journal Article 
Controlled Release of Curcumin via Folic Acid Conjugated Magnetic Drug Delivery System 
Song Shengmei; Li Minglu; Gong Xiaojuan; Han Hui; Zhou Yehong; Wang Li; Shuang Shaomin; Dong Chuan; , 
2018 
Yes 
Chemical Research in Chinese Universities
ISSN: 1005-9040 
HIGHER EDUCATION PRESS 
BEIJING 
203-211 
WOS:000433252100010 
In the paper, folic acid(FA)-mediated and beta-cyclodextrin(beta-CD) derivatives functionalized magnetic Fe3O4 nanoparticles(MNPs) were successfully prepared as drug carriers for the targeted delivery and controlled release of water-insoluble anticancer drug. FA-sulfobutyl ether-beta-CD-CD-MNPs(FA-SBE-beta-CD-CD-MNPs), FA-hydroxypropyl-beta-CD-CD-MNPs(FA-HP-beta-CD-CD-MNPs) and FA-carboxymethyl-beta-CD-CD-MNPs(FA-CM-beta-CDCD-MNPs) were fabricated, and the loading efficiency and relative entrapment rate of curcumin are 12.04 mg/g, 95.56% for FA-SBE-beta-CD-CD-MNPs, 9.6 mg/g, 81.63% for FA-HP-beta-CD-CD-MNPs and 7.88 mg/g, 85.28% for FA-CM-beta-CD-CD-MNPs, respectively. Meanwhile, at pH=5.0, the optimal release rate of curcumin is about 46.07% for FA-SBE-beta-CD-CD-MNPs in 5 h. Cellular uptake indicates that curcumin can be selectively transported to targeting site and released from the internalized carriers. The in vitro cytotoxicity reveals that non-toxic FA-SBE-beta-CD-CD-MNPs have excellent biocompatibility on HepG2 cells in the tested concentrations. Therefore, FA-SBE-beta-CD-CD-MNPs could provide a promising platform for the targeting delivery of water insoluble anti-cancer drugs for different treatment needs of cancer therapy.