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7146339 
Journal Article 
Axillary lymph node metastases with an occult breast: About 16 cases from a cohort of 7770 patients 
Couder, F; Schmitt, C; Treilleux, I; Tredan, O; Faure, C; Carrabin, N; Beurrier, F; Chopin, N; , 
2015 
0 
Gynecologie Obstetrique et Fertilite
ISSN: 1297-9589 
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER 
PARIS 
588-592 
26257298 
WOS:000362623400005 
Objectives. - Isolated axillary lymph node metastases is an unusual clinical presentation of breast carcinoma. We studied its different issues.Methods. - This study is a follow-up study of 16 patients, treated between 1996 and 2012, presenting with axillary metastases with an occult breast carcinoma, which could not be identified by physical examination nor by a conventional imaging or a breast MRI. Clinical characteristics, histological analysis, treatment, monitoring and five-year survival rate were studied.Results. - The incidence of this kind of breast cancer was 0.20%. A breast MRI was performed in 75% of the patients. The histology of these tumors showed a rate of hormono-sensibility of 50% and an HER2 overexpression of 44%. Sixty-nine percent of the patients had no breast surgery or radiotherapy; global five-year survival rate for these women was 77.4% +/- 11.5.Conclusion. - The survival rates of this study should lead the practitioner to choose a less aggressive breast therapy. Moreover, the histological characteristics explain the high metastatic potential of these tumors, and relate them to the HER2+ subclass of gene expression patterns of breast carcinomas. (C) 2015 Published by Elsevier Masson SAS.