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7146720 
Journal Article 
An OA phenotype may obtain major benefit from bone-acting agents 
Roman-Blas, JA; Castañeda, S; Largo, R; Lems, WF; Herrero-Beaumont, G; , 
2014 
1 
Seminars in Arthritis and Rheumatism
ISSN: 0049-0172
EISSN: 1532-866X 
W B SAUNDERS CO-ELSEVIER INC 
PHILADELPHIA 
421-428 
English 
24016748 
WOS:000331598400001 
Osteoarthritis (OA) joints display relevant microstructure alterations associated to an increase in remodeling at subchondral bone, which supports its crucial role in OA pathogenesis. Despite this, the treatment of knee OA patients with antiresorptive drugs has given discordant results, suggesting the existence of a particular patient subset with good response to halting high subchondral remodeling.