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7148663 
Journal Article 
Efficacy evaluation of prostaglandin E1 against placebo in patients with progressive systemic sclerosis and significant Raynaud's phenomenon 
Bartolone, S; Trifiletti, A; De Nuzzo, G; Scamardi, R; Larosa, D; Sottilotta, G; Raffa, A; Barbera, N; , 
1999 
1 
Minerva Cardioangiologica
ISSN: 0026-4725 
English 
10479851 
Raynaud's phenomenon, due to connective tissue diseases, is difficult to treat successfully. Symptomatic improvement has been reported using nifedipine or iloprost, but adverse side effects may limit their use. The purpose of this study was to examine the effects of PGE1 (Alprostadil) in patients with scleroderma and severe Raynaud's disease.