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Citation
Tags
HERO ID
7149619
Reference Type
Journal Article
Title
Double Edge Sword Behavior of Carbendazim: A Potent Fungicide With Anticancer Therapeutic Properties
Author(s)
Goyal, K; Sharma, A; Arya, R; Sharma, R; Gupta, GK; Sharma, AK; ,
Year
2018
Is Peer Reviewed?
1
Journal
Anti-Cancer Agents in Medicinal Chemistry
ISSN:
1871-5206
EISSN:
1875-5992
Publisher
BENTHAM SCIENCE PUBL LTD
Location
SHARJAH
Page Numbers
38-45
PMID
28003000
DOI
10.2174/1871520616666161221113623
Web of Science Id
WOS:000428133900007
Abstract
Background: A number of benzimidazole derivatives such as benomyl and carbendazim have been known for their potential role as agricultural fungicides. Simultaneously carbendazim has also been found to inhibit proliferation of mammalian tumor cells specifically drug and multidrug resistant cell lines.Objective: To understand the dual role of Carbendazim as a fungicide and an anticancer agent, the study has been planned referring to the earlier studies in literature.Results: Studies carried out with fungal and mammalian cells have highlighted the potential role of carbendazim in inhibiting proliferation of cells, thereby exhibiting therapeutic implications against cancer. Because of its promising preclinical antitumor activity, Carbendazim had undergone phase I clinical trials and is under further clinical investigations for the treatment of cancer. A number of theoretical interactions have been pinpointed. There are many anticancer drugs in the market, but their usefulness is limited because of drug resistance in a significant proportion of patients. The hunger for newer drugs drives anticancer drug discovery research on a global platform and requires innovations to ensure a sustainable pipeline of lead compounds.Conclusion: Current review highlights the dual role of carbendazim as a fungicide and an anticancer agent. Further, the harmful effects of carbendazim and emphasis upon the need for more pharmacokinetic studies and pharmacovigilance data to ascertain its clinical significance, have also been discussed.
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