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7153129 
Journal Article 
Integrating drug permeability with dissolution profile to develop IVIVC 
Takano, R; Kataoka, M; Yamashita, S; , 
2012 
Yes 
Biopharmaceutics and Drug Disposition
ISSN: 0142-2782
EISSN: 1099-081X 
WILEY 
HOBOKEN 
354-365 
22581486 
WOS:000309409500003 
In this review article, three different approaches to predict in vivo oral absorption based on the in vitro data of drug permeability, solubility and dissolution were introduced. At the drug discovery stage, the absorption potential of each candidate is most important to select better compounds for further development. The concept of maximum absorbable dose is applied widely, not only to evaluate the absorption potential but also to elucidate the rate-limiting process of oral absorption that helps us to understand the cause of poor absorption. To integrate the permeability of the drug with its dissolution profile, two different approaches, in vitro dissolution/permeation system (D/P system) and in silico model and simulation method, are proposed. In the D/P system, by mimicking the in vivo process of drug absorption, the permeated amount of drugs, that is the total output of dissolution and permeation processes, are correlated with the fraction absorbed in human (Fa). This system is powerful for evaluating the improved absorption by various formulations and the effect of food intake. On the other hand, in the model and simulation approach, an intrinsic dissolution parameter of drug particle, z, was extracted from the small scale in vitro test and the process of intestinal absorption was re-constructed in silico by incorporating the physiological parameters in human. The effective use of these approaches for the development of oral drug products is discussed through various case studies. Copyright (c) 2012 John Wiley & Sons, Ltd.