Health & Environmental Research Online (HERO)


Print Feedback Export to File
7159456 
Journal Article 
Th17-mediated inflammation in asthma 
Newcomb, DC; Peebles, RS; , 
2013 
Yes 
Current Opinion in Immunology
ISSN: 0952-7915 
CURRENT BIOLOGY LTD 
LONDON 
755-760 
English 
24035139 
WOS:000328719900014 
Asthma is a heterogeneous disease with many different phenotypes. Moderate and severe asthma phenotypes have been associated with increased neutrophils and increased Th17 cytokines, IL-17A, IL-17F, and IL-22, in the bronchoalveolar lavage fluid of patients. Th17 cytokines recruit neutrophils to the airway by increasing secretion of epithelial-derived neutrophilic chemokines. In addition, Th17 cytokines also induce mucous cell metaplasia and have pleotropic effects on airway smooth muscle resulting in airway narrowing. The role of Th17 cytokines in regulating Th2 cytokine expression and allergic airway inflammation remains unclear with conflicting reports. However, the role of Th17 cells in asthma will be answered in ongoing clinical trials with therapeutics targeting IL-17A and IL-17 receptor signaling.