Health & Environmental Research Online (HERO)


Print Feedback Export to File
7166584 
Journal Article 
Reciprocal Modulation Between Microglia and Astrocyte in Reactive Gliosis Following the CNS Injury 
Gao, Z; Zhu, Q; Zhang, Y; Zhao, Y; Cai, Lu; Shields, CB; Cai, Jun; , 
2013 
1 
Molecular Neurobiology
ISSN: 0893-7648 
SPRINGER 
NEW YORK 
48 
3 
690-701 
23613214 
WOS:000326714700024 
Reactive gliosis, also known as glial scar formation, is an inflammatory response characterized by the proliferation of microglia and astrocytes as well as astrocytic hypertrophy following injury in the central nervous system (CNS). The glial scar forms a physical and molecular barrier to isolate the injured area from adjacent normal nervous tissue for re-establishing the integrity of the CNS. It prevents the further spread of cellular damage but represents an obstacle to regrowing axons. In this review, we integrated the current findings to elucidate the tightly reciprocal modulation between activated microglia and astrocytes in reactive gliosis and proposed that modification of cellular response to the injury or cellular reprogramming in the glial scar could lead advances in axon regeneration and functional recovery after the CNS injury. 
Reactive gliosis; Glial scar; Microglia; Astrocyte; Central nervous system