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7167532 
Journal Article 
Altered cartilage mechanics and histology in knee osteoarthritis: relation to clinical assessment (ICRS Grade) 
Kleemann, RU; Krocker, D; Cedraro, A; Tuischer, J; Duda, GN; , 
2005 
1 
Osteoarthritis and Cartilage
ISSN: 1063-4584 
English 
16139530 
Substantial changes in articular cartilage composition and mechanical properties occur during the development of osteoarthritis (OA). While softening in the initial stage is reported and sometimes used as an indicator of early OA, there is a lack of data relating the macroscopic appearance of cartilage to its mechanical and histological properties in all stages of degeneration. Knowledge about the mechanical quality of the tissue is important for diagnostic reasons and the understanding of the development of OA.