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Citation
Tags
HERO ID
7170156
Reference Type
Journal Article
Title
Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy
Author(s)
O'Muircheartaigh, J; Vollmar, C; Barker, GJ; Kumari, V; Symms, MR; Thompson, P; Duncan, JS; Koepp, MJ; Richardson, MP; ,
Year
2011
Is Peer Reviewed?
1
Journal
Neurology
ISSN:
0028-3878
EISSN:
1526-632X
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Location
PHILADELPHIA
Page Numbers
34-40
PMID
21205693
Web of Science Id
WOS:000285682800010
Abstract
Objective: The aim of this study was to determine if there were focal cortical abnormalities in juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI.Methods: Twenty-eight patients with JME and a large sample of healthy controls were assessed using a series of neuropsychological tests as well as structural and diffusion tensor MRI (DTI). DTI measures assessed fractional anisotropy (FA) within a white matter skeleton.Results: Neuropsychological testing indicated subtle dysfunctions in verbal fluency, comprehension, and expression, as well as nonverbal memory and mental flexibility. Utilizing whole-brain voxel-based morphometry for gray matter MRI data and tract-based spatial statistics for white matter diffusion MRI data, we found reductions in gray matter volume (GMV) in the supplementary motor area and posterior cingulate cortex and reductions in FA in underlying white matter of the corpus callosum. Supplementary motor area FA predicted scores in word naming tasks and expression scores. Posterior cingulate cortex GMV and FA predicted cognitive inhibition scores on the mental flexibility task.Conclusions: The neuropsychological, structural, and tractography results implicate mesial frontal cortex, especially the supplementary motor area, and posterior cingulate cortex in JME. Neurology (R) 2011; 76:34-40
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