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Citation
Tags
HERO ID
7172560
Reference Type
Journal Article
Title
Voxel-based diffusion tensor magnetic resonance imaging evaluation of low-grade hepatic encephalopathy
Author(s)
Kumar, R; Gupta, RK; Elderkin-Thompson, V; Huda, A; Sayre, J; Kirsch, C; Guze, B; Han, S; Thomas, MA; ,
Year
2008
Is Peer Reviewed?
Yes
Journal
Journal of Magnetic Resonance Imaging
ISSN:
1053-1807
EISSN:
1522-2586
Publisher
JOHN WILEY & SONS INC
Location
HOBOKEN
Page Numbers
1061-1068
PMID
18425846
DOI
10.1002/jmri.21342
Web of Science Id
WOS:000255622700015
Abstract
Purpose: To quantify the changes in brain water diffusivity in hepatic encephalopathy (HE) associated with cirrhosis using diffusion tensor imaging (DTI) and to correlate with neuropsychological (NP) scores.Materials and Methods: DTI was performed in 14 patients with low-grade HE and age/gender-comparable 16 healthy controls. Whole brain mean diffusivity (MD) and fractional anisotropy (FA) maps were calculated, normalized to common space, smoothed, and compared voxel-by-voxel between groups using analysis of covariance with age included as a covariate. The average MD and FA values were also calculated from individual subjects for selected brain regions and correlated with the neuropsychological scores.Results: Patients with HE showed increased MD in the cortical gray and white matter and the internal capsule. Less extensive brain regions with decreased FA were observed in the bilateral frontal and occipital white matter. MD values from the corpus callosum correlated inversely with several NP scores among HE patients and controls. Positive correlations were observed with FA values and cognitive scores.Conclusion: Voxel-based DTI analysis showed widespread brain regions with increased MD values, indicating enhanced water content and decreased FA in cirrhotic patients with HE. The MD and FA values from selected regions correlated with the NP scores.
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