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7173050 
Journal Article 
A review of multisite pacing to achieve cardiac resynchronization therapy 
Rinaldi, CA; Bordachar, P; Leclercq, C; Burri, H; Thibault, B; Curnis, A; Raos, A; Gras, D; Sperzel, J; Singh, JP; Biffi, M; , 
2015 
Yes 
Europace
ISSN: 1099-5129
EISSN: 1532-2092 
OXFORD UNIV PRESS 
OXFORD 
7-17 
25214507 
WOS:000351603900004 
Non-response to cardiac resynchronization therapy remains a significant problem in up to 30% of patients. Multisite stimulation has emerged as a way of potentially overcoming non-response. This may be achieved by the use of multiple leads placed within the coronary sinus and its tributaries (dual-vein pacing) or more recently by the use of multipolar (quadripolar) left ventricular pacing leads which can deliver pacing stimuli at multiple sites within the same vein. This review covers the role of multisite pacing including the interaction with the underlying pathophysiology, the current and planned studies, and the potential pitfalls of this technology.