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7174083 
Journal Article 
Effect of toothpaste containing arginine on dental plaque-A randomized controlled in situ study 
Xue, Y; Lu, Q; Tian, Y; Zhou, X; Cheng, Lei; Ren, B; , 
2017 
Yes 
Journal of Dentistry
ISSN: 0300-5712
EISSN: 1879-176X 
ELSEVIER SCI LTD 
OXFORD 
67 
88-93 
English 
28987625 
WOS:000417204800013 
Objectives: To evaluate the effects of 8% arginine-containing toothpaste on the dental plaque of no caries (NC) and high caries (HC) individuals in situ.Methods: 6 no caries (DMFT = 0) and 6 high caries (DMFT = 6) individuals wearing a self-developed in situ dental plaque acquisition device were involved in a randomized double-blinded crossover study for 6 weeks: including lead-in (1 week), arginine-free (2 weeks), washout (1 week) and arginine-active (2 weeks) stages. The in situ plaque samples were collected at the endpoint of arginine-free and arginine-active stages and subjected to lactic acid production, metabolic activity, live/dead bacteria ratio and total biofilm biomass detections.Results: The arginine-containing dentifrice reduced lactic acid production significantly in both the NC and HC groups, while the inhibitory abilities in the HC group were stronger than that in the NC group. In addition, the arginine-containing dentifrice didn't significantly decrease the metabolic activity, live/dead bacteria ratio and total biofilm biomass in either the NC or the HC group.Conclusions: Arginine-containing toothpaste can significantly reduce the lactic acid production from the in situ plaques to a low level without changing the metabolic activity, live/dead bacteria ratio and total biofilm biomass through a critical clinical randomized double-blinded crossover study.Clinical significance: Arginine is a potential ecological prevention and control agent for dental caries. Meanwhile, the in situ model is an easy and pragmatic way to evaluate oral hygiene products.