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Citation
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HERO ID
7176613
Reference Type
Journal Article
Title
Simplified captopril analogues as NDM-1 inhibitors
Author(s)
Li, N; Wang, J; Zhou, HG; Xu, F; Yang, C; Zhang, Q; Yin, Z; Guo, Yu; Chen, Yue; Xu, Y; Xia, Q; Bai, C; Wang, T; Wang, Lei; He, D; Xie, N; Li, L; ,
Year
2014
Is Peer Reviewed?
Yes
Journal
Bioorganic & Medicinal Chemistry Letters
ISSN:
0960-894X
EISSN:
1464-3405
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Page Numbers
386-389
PMID
24269122
DOI
10.1016/j.bmcl.2013.10.068
Web of Science Id
WOS:000329114200076
Abstract
Captopril is a New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9 mu M. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, we synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors in order to identify the pharmacophore for NDM-1 inhibition. We found that the lead compound 22 had an IC50 value of 1.0 mu M. Further structure simplification provided compounds 31 and 32, which had IC50 values of 15 and 10 mu M, respectively. As compound 32 is a clinically used antidote for metal poisoning, it has great potential to be repurposed to treat bacterial infections. (c) 2013 Elsevier Ltd. All rights reserved.
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