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7182193 
Journal Article 
Cardiac resynchronization therapy guided by multimodality cardiac imaging 
Bertini, M; Campagnolo, E; Benea, G; Ferrari, R; Mele, D; Malagu, M; Fiorencis, A; Toselli, T; Casadei, F; Cannizzaro, T; Fragale, C; Fucili, A; , 
2016 
Yes 
European Journal of Heart Failure
ISSN: 1388-9842 
WILEY-BLACKWELL 
HOBOKEN 
1375-1382 
27406979 
WOS:000387343900012 
AimsUp to 30-45% of implanted patients are non-responders to CRT. We evaluated the role of a CRT team' using cardiac magnetic resonance (CMR) and longitudinal myocardial strain to identify the target area defined as the most delayed and viable region for LV pacing.Methods and resultsA total of 100 heart failure patients candidates for CRT divided into two groups were enrolled. Group 1 consisted of 50 consecutive patients scheduled for CRT and prospectively included. Group 2 (control) consisted of 50 patients with a CRT device implanted according to standard clinical practice and matched for age, sex, and LVEF with group 1. Patients were evaluated at baseline and at 6-month follow-up. In group 1, patients underwent two-dimensional speckle-tracking assessment of longitudinal myocardial strain and CMR imaging to identify the target area for LV lead pacing. A positive response to CRT was defined as a reduction of 15% of the LV end-systolic volume at 6-month follow-up. A total of 39 (78%) patients of group 1 were classified as responders to CRT whilst in group 2, only 28 (56%) were responders (P = 0.019). The CRT team' identified as target for LV pacing the lateral area in 30 (60%) patients, and the anterolateral or posterolateral areas in 12 (24%) patients. In 8 (16%) patients, the target was far from the lateral area, in the anterior or posterior areas. The patients with concordant position exhibited the highest positive response (93.1%) to CRT.ConclusionsMultimodality cardiac imaging as a guide for CRT implantation is useful to increase response rate.