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7184857 
Journal Article 
Potential blood clotting factors and anticoagulants 
Jin, NZ; Gopinath, SCB; , 
2016 
Yes 
Biomedicine & Pharmacotherapy
ISSN: 0753-3322
EISSN: 1950-6007 
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER 
PARIS 
356-365 
English 
27668535 
WOS:000390438100039 
Hemostasis initiates a wound healing process and stops bleeding of blood within a damaged tissue, an important process in human and animal systems. However, this process needs to revert temporarily during surgery and analyze the clotting mechanism. In the past decade, heparin has been used widely as an anticoagulant in surgery to prevent unwanted blood clotting as it is not expensive, not difficult to control, lack of suitable replacement as well as less harmful to the human. However, heparin has several disadvantages, which include thrombocytopenia and non-specific plasma binding. Moreover, using heparin it may lead dysfunction and platelet aggregation. In this overview, potential clotting factors and anticoagulants are reviewed and special focus was given to get more insights.