Billiard, J; Dennison, JB; Briand, J; Annan, RS; Chai, D; Colón, M; Dodson, CS; Gilbert, SA; Greshock, J; Jing, J; Lu, H; Mcsurdy-Freed, JE; Orband-Miller, LA; Mills, GB; Quinn, CJ; Schneck, JL; Scott, GF; Shaw, AN; Waitt, GM; Wooster, RF; Duffy, KJ; ,
Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerobic glycolysis. This glycolytic phenotype is enabled by lactate dehydrogenase (LDH), which catalyzes the inter-conversion of pyruvate and lactate. The purpose of this study was to identify and characterize potent and selective inhibitors of LDHA.