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HERO ID
7191552
Reference Type
Journal Article
Title
Cellular fatty acid uptake: a pathway under construction
Author(s)
Su, X; Abumrad, NA; ,
Year
2009
Is Peer Reviewed?
1
Journal
Trends in Endocrinology and Metabolism
ISSN:
1043-2760
EISSN:
1879-3061
Publisher
ELSEVIER SCIENCE LONDON
Location
LONDON
Page Numbers
72-77
PMID
19185504
DOI
10.1016/j.tem.2008.11.001
Web of Science Id
WOS:000264571100004
Abstract
Membrane uptake of long-chain fatty acids (FAs) is the first step in cellular FA utilization and a point of metabolic regulation. CD36 facilitates a major fraction of FA uptake by key tissues. This review highlights the contribution of CD36 to pathophysiology in rodents and humans. Novel concepts regarding regulation of CD36-facilitated uptake are discussed (i.e. the role of membrane rafts and caveolae, CD36 recycling between intracellular depots and the membrane, and chemical modifications of the protein that impact its turnover and recruitment). Importantly, CD36 membrane levels and turnover are abnormal in diabetes, resulting in dysfunctional FA utilization. In addition, variants in the CD36 gene were shown recently to influence susceptibility for the metabolic syndrome, which greatly increases the risk of diabetes and heart disease.
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