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7194623 
Journal Article 
Supramolecular assembly based on host-guest interaction between beta-cyclodextrin and adamantane for specifically targeted cancer imaging 
Lee, DWon; Jo, J; Jo, D; Kim, J; Min, JJ; Yang, DaeH; Hyun, H; , 
2018 
Yes 
Journal of Industrial and Engineering Chemistry
ISSN: 1226-086X 
ELSEVIER SCIENCE INC 
NEW YORK 
37-44 
WOS:000422811600005 
Accurate diagnosis of tumor and targeted drug delivery are prerequisites to effectively treat tumors with minimum side effects. In this study, beta-cyclodextrin (beta-CD), polyethylene glycol (PEG), and folic acid (FA) were combined as a flatform (CDPF) to effectively transport adamantane (ADM) and near-infrared fluorophore (NIRF) conjugate (ADM-NIRF) to tumor target site. Using a tumor-bearing xenograft mouse model, the supramolecular assembly exhibited excellent tumor targetability because the FA component could strongly bind to folate-receptors overexpressed in the membrane of MCF7 human breast adenocarcinoma cells compared to ADM-NIRF. These results indicate that CDPF-ADM-NIRF has potential as a tumor diagnosis agent for clinical use. (c) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.