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7196073 
Journal Article 
A very high dose dexamethasone suppression test for differential diagnosis of Cushing's syndrome 
Al-Saadi, N; Diederich, S; Oelkers, W; , 
1998 
Yes 
Clinical Endocrinology
ISSN: 0300-0664
EISSN: 1365-2265 
English 
9509067 
The high-dose dexamethasone (dex) suppression test of cortisol secretion (8 x 2 mg dex over two days or 8 mg overnight) is a mainstay in the differential diagnosis of Cushing's syndrome (CS). In some patients with pituitary Cushing's disease (CD), however, plasma cortisol is not suppressed to < 50% of control by 8 mg of dex. We therefore hypothesized that a higher dose of dex might produce more effective suppression of cortisol secretion in CD.