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HERO ID
7201503
Reference Type
Journal Article
Title
Synthesis and biological evaluation of novel 3,9-substituted β-carboline derivatives as anticancer agents
Author(s)
Chen, YF; Lin, YC; Chen, JP; Chan, HC; Hsu, MH; Lin, HY; Kuo, SC; Huang, LJ; ,
Year
2015
Is Peer Reviewed?
Yes
Journal
Bioorganic & Medicinal Chemistry Letters
ISSN:
0960-894X
EISSN:
1464-3405
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Volume
25
Issue
18
Page Numbers
3873-3877
Language
English
PMID
26235951
DOI
10.1016/j.bmcl.2015.07.058
Web of Science Id
WOS:000359747700021
Abstract
In our previous studies on 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) analogs, we synthesised numerous substituted carbazole and α-carboline derivatives, which exhibited anticancer activity. In this study, we designed and synthesised a series of 3,9-substituted β-carbolines, by replacing the tricyclic rings of carbazole and α-carboline derivatives with isosteric β-carboline, and evaluated anticancer activity. We observed that 9-(2-methoxybenzyl)-β-carboline-3-carboxylic acid (11a) inhibited the growth of HL-60 cells by inducing apoptosis, with a half maximal inhibitory concentration of 4.0 μM. Our findings indicate that β-carboline derivatives can be used as lead compounds for developing novel antitumor agents.
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