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7204020 
Journal Article 
Family based association study with complex survey data 
She, D; Zhang, H; Li, Yan; Graubard, BI; Li, Z; , 
2014 
0 
Statistics and its Interface
ISSN: 1938-7989 
INT PRESS BOSTON, INC 
SOMERVILLE 
7 
2 
167-176 
WOS:000335388500002 
Genetic data collected from the Third National Health and Nutrition Examination Survey (NHANES III) provides an opportunity to investigate associations between genetic variations and health-related phenotypes for the US population. Complex sample designs involving stratified multistage cluster sampling and sample weighting are used to sample families in household surveys such as the NHANES III. We modified conditional likelihood score and trend tests used to test the null hypothesis of no association between a candidate gene and a phenotype in simple random samples of nuclear families so that these tests are applicable to data from complex sample designs. The finite sample properties of our modified test procedures are evaluated via Monte Carlo simulation studies. We recommend using an F-version of the trend test instead of a score test because the F-test shows greater power. Our test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, VDR (rs2239185) and high blood lead level, and TGFB1 (rs1982073) and asthma. 
Complex sampling; Conditional likelihood score test; Nuclear family; Survey data; Trend test