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7210306 
Journal Article 
The high affinity IgE receptor (Fc epsilon RI) expression and function in airway smooth muscle 
Redhu, NS; Gounni, AS; , 
2013 
1 
Pulmonary Pharmacology and Therapeutics
ISSN: 1094-5539
EISSN: 1522-9629 
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 
LONDON 
86-94 
22580035 
WOS:000315015100010 
The airway smooth muscle (ASM) is no longer considered as merely a contractile apparatus and passive recipient of growth factors, neurotransmitters and inflammatory mediators signal but a critical player in the perpetuation and modulation of airway inflammation and remodeling. In recent years, a molecular link between ASM and IgE has been established through Fc epsilon receptors (Fc epsilon Rs) in modulating the phenotype and function of these cells. Particularly, the expression of high affinity IgE receptor (Fa epsilon I) has been noted in primary human ASM cells in vitro and in vivo within bronchial biopsies of allergic asthmatic subjects. The activation of Fc epsilon RI on ASM cells suggests a critical yet almost completely ignored network which may modulate ASM cell function in allergic asthma. This review is intended to provide a historical perspective of IgE effects on ASM and highlights the recent updates in the expression and function of Fc epsilon RI, and to present future perspectives of activation of this pathway in ASM cells. (C) 2012 Elsevier Ltd. All rights reserved.