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7213213 
Journal Article 
Synthesis and Anti-tumor Activities of Novel 4 '-(N-Substitued-1-piperazinyl)chalcone Derivatives 
Lin Yuping; Hu Chunyan; Zheng Xi; Wang Xiuli; Wan Chunping; Mao Zewei; , 
2017 
1 
Youji Huaxue / Chinese Journal of Organic Chemistry
ISSN: 0253-2786 
SCIENCE PRESS 
BEIJING 
237-241 
WOS:000396298200029 
With the aim of developing new potent anticancer agents, a series of novel 4'-(N-substitued-l-piperazinyl)chalcone derivatives 3a similar to 3j have been designed and synthesized based on the structure of the chalcone by molecular hybridization. The structures were characterized by H-1 NMR, C-13 NMR and HRMS. These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines (Hela, A549 and SGC7901) by the thiazolyl blue tetrazolium bromide (MTT) assay. The result indicated that compounds 3f, 3i and 3j were found to be the potent compounds against human tumor cell lines, which are to be lead compounds for further structural modifications and activity research.