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7219565 
Journal Article 
Structural Modification for Antitumor Nitrogenous Steroids 
Xie Tian-Peng; Yang Kang; Zhang Li-Zhi; Chen De-Sheng; Zou Kun; Huang Nian-Yu; , 
2017 
Yes 
Chinese Journal of Structural Chemistry
ISSN: 0254-5861 
CHINESE JOURNAL STRUCTURAL CHEMISTRY 
FUJIAN 
36 
12 
2007-2019 
WOS:000419109200007 
Natural steroids have been showing notable cytotoxic activities, which are quite interesting lead compounds for the development of anticancer drug including estramustine and prednimustine. Considering that these semi-synthetic molecules are nitrogen mustard functionalized steroidal derivatives, the present review is focused on the methodologies of introducing nitrogen atom or nitrogen-containing heterocycles on A similar to D rings or side chains of steroids, and analysis of the structure-activity relationship (SAR) for these man-made cytotoxic steroids.