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7220807 
Journal Article 
Synthesis and anticancer evaluation of indazole-aryl hydrazide-hydrazone derivatives 
Rudavath, D; Sreenivasulu, R; Pinapati, SRao; Raju, RR; , 
2018 
Yes 
Journal of the Indian Chemical Society
ISSN: 0019-4522 
SCIENTIFIC PUBL-INDIA 
JODHPUR 
433-438 
WOS:000433977400006 
A new series of hydrazide-hydrazones linked between indazole and substituted benzaldehydes were designed, synthesized and evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7 and A549). Among the synthesized compounds 10a, 10e, and 10h showed promising cytotoxicity specifically on some of the tested cell lines with IC50 values of 2.1 (HeLa), 2.37 (MCF-7) and 1.39 (MCF-7) respectively. The compound 10a exhibited its potent activity especially on HeLa cell line. Further, the compound 10e was identified as a promising drug lead which showed promising cytotoxicity with IC50 value of 1.39 mu M towards MCF-7 breast cancer cell line as compared with standard drug doxorubicin (IC50 value 0.54 mu M). While all these new compounds showed no cytotoxicity on the normal human embryonic kidney cell line, HEK-293.