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7222718 
Journal Article 
Hemostatic effects of the ticagrelor antidote MEDI2452 in pigs treated with ticagrelor on a background of aspirin 
Pehrsson, S; Johansson, KJ; Janefeldt, A; Sandinge, AS; Maqbool, S; Goodman, J; Sanchez, J; Almquist, J; Gennemark, P; Nylander, S; , 
2017 
1 
Journal of Thrombosis and Haemostasis
ISSN: 1538-7933
EISSN: 1538-7836 
15 
6 
1213-1222 
English 
28322016 
Essentials MEDI2452 is a specific antidote of the platelet P2Y12 receptor antagonist ticagrelor. Hemostatic effects of MEDI2452 were evaluated in pigs treated with ticagrelor and aspirin. MEDI2452 eliminated free ticagrelor within 5 min and gradually normalized platelet aggregation. Improvements in blood pressure (significant) and in blood-loss and survival (non-significant) were observed.