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7223057 
Journal Article 
Impact of Drug Metabolism/Pharmacokinetics and their Relevance Upon Salviabased Drug Discovery 
Hao, DC; Xiao, PG; , 
2017 
Yes 
Current Drug Metabolism
ISSN: 1389-2002
EISSN: 1875-5453 
English 
28558633 
Salvia is the largest genus of family Lamiaceae and has nearly 1000 species. This genus produces several representative phytometabolites, e.g., diterpenoids and phenolic acids. The traditional uses in ethnomedicine and contemporary experimental studies have corroborated extensive therapeutic efficacy of Salvia plants. Drug metabolism and pharmacokinetic (DMPK) studies of Salvia natural products and their derivatives are indispensable in the optimization of lead compounds. New chemical entity with improved DMPK profiles is preferred. So far, there are few summaries concerning about the DMPK features of Salvia derived medicinal compounds. Tanshinones and Salvianolic acids raise concerns of herb-drug interaction. DMPK studies of various Salvia species, especially Salvia miltiorrhiza, are swiftly increasing.