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7245344 
Journal Article 
Resolution of inflammation: a new therapeutic frontier 
Fullerton, JN; Gilroy, DW; , 
2016 
1 
Nature Reviews. Drug Discovery
ISSN: 1474-1776
EISSN: 1474-1784 
NATURE PUBLISHING GROUP 
LONDON 
551-567 
27020098 
WOS:000382531000016 
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes - a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.