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7248427 
Journal Article 
In vivo kinetic study of materno-fetal fatty acid transfer in obese and normal weight pregnant women 
Gázquez, A; Prieto-Sánchez, MT; Blanco-Carnero, JE; van Harskamp, D; Perazzolo, S; Oosterink, JE; Demmelmair, H; Schierbeek, H; Sengers, BG; Lewis, RM; van Goudoever, JB; Koletzko, B; Larqué, E; , 
2019 
Yes 
Journal of Physiology
ISSN: 0022-3751
EISSN: 1469-7793 
WILEY 
HOBOKEN 
4959-4973 
English 
31287560 
WOS:000479547100001 
Placental structure and function can be modified as a result of maternal obesity affecting materno-fetal fatty acids (FA) transport. We report for the first time, in humans and in vivo, the kinetics of placental FA transfer in normo-weight and in normolipemic obese pregnant women using stable isotopes. The administration of different tracer FA with similar behaviour to the mother at different time points allows the collection of kinetic information on materno-fetal transfer of FA despite only one sample of placenta and cord can be collected per subject. Computational modelling showed a good fit to the data when considering all maternal plasma lipid classes but not when based only on non-esterified FA. The novel approach using multiple tracer FA administration combined with computational modelling shows a consistent time course of placental tracer FA and predicted total FA accumulation.