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7250025 
Journal Article 
Circulating succinate is elevated in rodent models of hypertension and metabolic disease 
Sadagopan, N; Li, W; Roberds, SL; Major, T; Preston, GM; Yu, Y; Tones, MA; , 
2007 
Yes 
American Journal of Hypertension
ISSN: 0895-7061 
ELSEVIER SCIENCE INC 
NEW YORK 
1209-1215 
English 
17954369 
WOS:000250963900013 
Recent evidence suggests that succinate, long known as an intermediate in the citric acid cycle, may also have a role as a signaling molecule through GPR91 and that activation of this receptor results in blood pressure (BP) elevation via the renin-angiotensin system. We sought to test the hypothesis that GPR91 contributes to BP elevation in hypertension. In addition we investigated whether elevated succinate in diabetes could contribute to the increased rate of gluconeogenesis in that condition.