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7254952 
Journal Article 
Positive Association of Fibroadenomatoid Change with HER2-Negative Invasive Breast Cancer: A Co-Occurrence Study 
Chen, Y; Bekhash, A; Kovatich, AJ; Hooke, JA; Liu, J; Kvecher, L; Fantacone-Campbell, JL; Mitchell, EP; Rui, H; Mural, RJ; Shriver, CD; Hu, H; , 
2015 
1 
PLoS ONE
EISSN: 1932-6203 
PUBLIC LIBRARY SCIENCE 
SAN FRANCISCO 
English 
26098961 
WOS:000356835800031 
Risk assessment of a benign breast disease/lesion (BBD) for invasive breast cancer (IBC) is typically done through a longitudinal study. For an infrequently-reported BBD, the shortage of occurrence data alone is a limiting factor to conducting such a study. Here we present an approach based on co-occurrence analysis, to help address this issue. We focus on fibroadenomatoid change (FAC), an under-studied BBD, as our preliminary analysis has suggested its previously unknown significant co-occurrence with IBC.