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7265094 
Journal Article 
Effects of a peptidoheteroglycan prepared from Chlorella Pyrenoidosa (Chlorophyceae) on complement C3 and peritoneal macrophages 
Itoh, H; Kakinuma, M; Fujishima, M; Arakawa, Y; Nakata, F; Ito, H; , 
2015 
1 
Nippon Suisan Gakkaishi
ISSN: 0021-5392 
JAPANESE SOC FISHERIES SCIENCE 
TOKYO 
267-273 
WOS:000351319700007 
We purified a peptidoheteroglycan (FA-1a) from Chlorella pyrenoidosa and investigated its effects on the third component of complement (C3) and peritoneal macrophages activation. In crossed immunoelectrophoresis, human serum C3 was converted by FA-la and ATSO (positive control), and appeared as the third peak (converted C3). After oral administration (p.o.) of FA-la to mice, the binding of C3 cleavage product (C3b) to peritoneal macrophages and the proportion of C3 positive cells were increased as shown by the immunotluorescent antibody technique. These activated macrophages enhanced phagocytosis of polystyrene latex beads. This is the first report showing that p.o. of FA-la prepared from Chlorella pyrenoidosa is capable of activating C3 and macrophages. The present results indicate that FA-la may open new perspectives in immuno-chemotherapy.