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HERO ID
7270072
Reference Type
Journal Article
Title
Acute e-cig inhalation impacts vascular health: A study in smoking naïve subjects
Author(s)
Chatterjee, S; Caporale, A; Tao, JQ; Guo, W; Johncola, AJ; Strasser, AA; Leone, FT; Langham, MC; Wehrli, FW
Year
2021
Is Peer Reviewed?
Yes
Journal
American Journal of Physiology: Heart and Circulatory Physiology
ISSN:
0363-6135
EISSN:
1522-1539
Volume
320
Issue
1
Page Numbers
H144-H158
Language
English
PMID
33216614
DOI
10.1152/ajpheart.00628.2020
Web of Science Id
WOS:000613249500007
Abstract
This study was designed to investigate the acute effects of nonnicotinized e-cigarette (e-cig) aerosol inhalation in nonsmokers both in terms of blood-based markers of inflammation and oxidative stress and evaluate their association with hemodynamic-metabolic MRI parameters quantifying peripheral vascular reactivity, cerebrovascular reactivity, and aortic stiffness. Thirty-one healthy nonsmokers were subjected to two blood draws and two identical MRI protocols, each one before and after a standardized e-cig vaping session. After vaping, the serum levels of C-reactive protein, soluble intercellular adhesion molecule, and the danger signal machinery high-mobility group box 1 (HMGB1) and its downstream effector and the NLR family pyrin domain containing 3 (NLRP3) inflammasome (as monitored by its adaptor protein ASC) increased significantly relative to the respective baseline (prevaping) values. Moreover, nitric oxide metabolites and reactive oxygen species production decreased and increased, respectively. These observations were paralleled by impaired peripheral vascular reactivity (with reduced flow-mediated dilation and attenuated hyperemic response after a cuff-occlusion test) and metabolic alterations expressed by decreased venous oxygen saturation, postvaping. The current results suggest propagation of inflammation signaling via activation of the danger signaling axis (HMGB1-NLRP3). The findings indicate that a single episode of vaping has adverse impacts on vascular inflammation and function. NEW & NOTWORTHY Endothelial cell signaling and blood biomarkers were found to correlate with functional vascular changes in a single episode e-cigarettes inhalation in healthy adults. This is indicative of the potential of e-cigarettes (even when inhaled acutely) to lead of vascular dysfunction.
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