US EPA

7271280 

Journal Article 

EFFECT OF CHRONIC APPLICATION OF QUERCETIN AND ACUTE DOSE OF T-2 TOXIN ON HAEMATOLOGICAL PARAMETERS OF RABBITS 

Petruska, P; Capcarova, M; , 

2012 

MENDEL UNIV BRNO, FAC AGRONOMY 

BRNO 

981-988 

WOS:000366461200113 

The aim of the present study was to determine effect of chronic application of quercetin in various doses and acute dose of T-2 toxin on selected haematological parameters of rabbits blood. Animals were divided into two control groups (Cl and C2) and experimental groups (E1 - E6). Experimental groups received quercetin in injectable form at 10 mu g.kg(-1) in El and E2 group, 100 mu g.kg(-1) in E3 and E4 group and 1000 mu g.kg(-1) in E5 and E6 group without T-2 toxin for 90 days. T-2 toxin (Romer Labs Division Holding GmbH, Tulin, Austria) to C2, E2, E4 and E6 group at dose 0.08mg per kgof body weight 72 hours before slaughter was applied. Significant increase (P< 0.05) of MI% (medium-size cell percentage) in E3 (100 mu g.kg(-1) of quercetin), E4 (100 mu g.kg(-1) of quercetin and 0.08 mg.kg(-1) of body weight) and E5 (1000 mu g.kg(-1) of quercetin) groups in comparison with the control group (Cl) was observed. Significant increase of MI% in E2 (10 mu g.kg(-1) of quercetin and 0.08 mg.kg(-1) of body weight), E3, E4, E5 and E6 (1000 mu g.kg(-1) of quercetin and 0.08 mg.kg(-1) of body weight) in comparison with El (10 mu g.kg(-1) of quercetin) was observed. Also we observed significant (P< 0.05) increase of MI% in E3 group vs. control group (C2).Higher values in WBC (total white blood cell count), MID (medium-size cell count) and LYM (lymphocytes count) in experimental groups and insignificant decrease of LY% (lymphocyte percentage) and GRA% (granulocytes percentage) in comparison with the control group was found. Other haematological parameters were not influenced by this natural antioxidant and T-2 toxin. 

Skarpa, P; Ryant, P; Cerkal, R; Polak, O; Kovarnik, J; Vyskocil, I; 

MendelNet International Ph.D. Students Conference 

Brno, CZECH REPUBLIC