Ni-Catalyzed hydrocyanation of alkenes with formamide as the cyano source (Electronic supplementary information (ESI) available: Experimental details and characterisation of products. See DOI: 10.1039/c9gc04275j) | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

7274656

Reference Type

Journal Article

Title

Ni-Catalyzed hydrocyanation of alkenes with formamide as the cyano source (Electronic supplementary information (ESI) available: Experimental details and characterisation of products. See DOI: 10.1039/c9gc04275j)

Author(s)

Xiao, S; Yuan-Yuan, J; Kang, L; Luo, Y

Year

2020

Is Peer Reviewed?

Yes

Journal

Green Chemistry
ISSN: 1463-9262
EISSN: 1463-9270

Volume

Issue

Page Numbers

2734-2738

Language

English

DOI

10.1039/c9gc04275j

URL

https://search.proquest.com/scholarly-journals/ni-catalyzed-hydrocyanation-alkenes-with/docview/2400280592/se-2?accountid=171501
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Abstract

“CN” generation from formamide dehydration! A novel Ni-catalyzed hydrocyanation of various alkenes to provide aliphatic nitriles is developed by generating hydrocyanic acid in situ from safe and readily available formamide. Excellent linear or branched regio-selectivity, wide substrate scope, cheap and stable nickel salt as a pre-catalyst, a safe cyano source, slow generation of “CN” to obviate catalyst deactivation and convenient experimental operation would render this hydrocyanation attactive for laboratory synthesis of aliphatic nitriles.

Keywords

Environmental Studies; Alkenes; Dehydration; Cyanide; Deactivation; Substrates; Catalysts; Aliphatic compounds; Nitriles; Hydrocyanic acid; Selectivity