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HERO ID
7279980
Reference Type
Journal Article
Subtype
Review
Title
Recent Development in Therapeutic Cardiac Patches
Author(s)
Mei, X; Cheng, K
Year
2020
Journal
Frontiers in Cardiovascular Medicine
ISSN:
2297-055X
Volume
7
Page Numbers
610364
Language
English
PMID
33330673
DOI
10.3389/fcvm.2020.610364
Web of Science Id
WOS:000597282300001
Abstract
For the past decades, heart diseases remain the leading cause of death worldwide. In the adult mammalian heart, damaged cardiomyocytes will be replaced by non-contractile fibrotic scar tissues due to the poor regenerative ability of heart, causing heart failure subsequently. The development of tissue engineering has launched a new medical innovation for heart regeneration. As one of the most outstanding technology, cardiac patches hold the potential to restore cardiac function clinically. Consisted of two components: therapeutic ingredients and substrate scaffolds, the fabrication of cardiac patches requires both advanced bioactive molecules and biomaterials. In this review, we will present the most state-of-the-art cardiac patches and analysis their compositional details. The therapeutic ingredients will be discussed from cell sources to bioactive molecules. In the meanwhile, the recent advances to obtain scaffold biomaterials will be highlighted, including synthetic and natural materials. Also, we have focused on the challenges and potential strategies to fabricate clinically applicable cardiac patches.
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