US EPA

7283994 

Journal Article 

Review 

Current Contributions of Organofluorine Compounds to the Agrochemical Industry 

Ogawa, Y; Tokunaga, E; Kobayashi, O; Hirai, K; Shibata, N 

2020 

1 

iScience
ISSN: 2589-0042 

23 

9 

101467 

English 

32891056 

10.1016/j.isci.2020.101467 

WOS:000577097800006 

Currently, more than 1,200 agrochemicals are listed and many of these are regularly used by farmers to generate the food supply to support the expanding global population. However, resistance to pesticides is an ever more frequently occurring phenomenon, and thus, a continuous supply of novel agrochemicals with high efficiency, selectivity, and low toxicity is required. Moreover, the demand for a more sustainable society, by reducing the risk chemicals pose to human health and by minimizing their environmental footprint, renders the development of novel agrochemicals an ever more challenging undertaking. In the last two decades, fluoro-chemicals have been associated with significant advances in the agrochemical development process. We herein analyze the contribution that organofluorine compounds make to the agrochemical industry. Our database covers 424 fluoro-agrochemicals and is subdivided into several categories including chemotypes, mode of action, heterocycles, and chirality. This in-depth analysis reveals the unique relationship between fluorine and agrochemicals.