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7298925 
Journal Article 
Review 
Aptamer Bioinformatics 
Kinghorn, AB; Fraser, LA; Lang, S; Shiu, SCC; Tanner, JA 
2017 
Yes 
International Journal of Molecular Sciences
ISSN: 1422-0067
EISSN: 14220067 
18 
12 
English 
29186809 
WOS:000418896700020 
Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular binding. They are isolated via SELEX (Systematic Evolution of Ligands by Exponential Enrichment), an evolutionary process that involves iterative rounds of selection and amplification before sequencing and aptamer characterization. As aptamers are genetic in nature, bioinformatic approaches have been used to improve both aptamers and their selection. This review will discuss the advancements made in several enclaves of aptamer bioinformatics, including simulation of aptamer selection, fragment-based aptamer design, patterning of libraries, identification of lead aptamers from high-throughput sequencing (HTS) data and in silico aptamer optimization.