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HERO ID
7322093
Reference Type
Journal Article
Title
HIV incidence in young girls in KwaZulu-Natal, South Africa--public health imperative for their inclusion in HIV biomedical intervention trials
Author(s)
Abdool Karim, Q; Kharsany, AB; Frohlich, JA; Werner, L; Mlotshwa, M; Madlala, BT; Abdool Karim, SS
Year
2012
Is Peer Reviewed?
Yes
Journal
AIDS & Behavior
ISSN:
1090-7165
Volume
16
Issue
7
Page Numbers
1870-1876
Language
English
PMID
22618892
DOI
10.1007/s10461-012-0209-y
Abstract
Young women are particularly vulnerable for acquiring HIV yet they are often excluded from clinical trials testing new biomedical intervention. We assessed the HIV incidence and feasibility of enrolling a cohort of young women for potential participation in future clinical trials. Between March 2004 and May 2007, 594 HIV uninfected 14-30 year old women were enrolled into a longitudinal HIV risk reduction study in KwaZulu-Natal, South Africa. The overall HIV prevalence at screening in young girls below the age of 18 years was 27.6 % compared to 52.0 % in the women above 18 years, p < 0.001. HIV incidence was 4.7 [95 % Confidence interval (CI) 1.5-10.9) and 6.9 (95 % CI 4.8-9.6)/100 women years (wy), p = 0.42 and pregnancy rates were 23.7 (95 % CI 14.9-35.9) and 16.4 (95 % CI 12.9-20.6)/100 wy, p = 0.29, in the women below and above 18 years respectively. Retention was similar in both groups (71.0 vs. 71.5 %, p = 0.90). This study demonstrates that the inclusion of young girls between the ages of 14 and 17 years in longitudinal studies is feasible and their inclusion in clinical trials would maintain scientific integrity and power of the study.
Keywords
Biomedical HIV prevention research; South Africa; Young girls; adolescent; article; clinical trial (topic); feasibility study; female; follow up; human; Human immunodeficiency virus infection; Human immunodeficiency virus prevalence; incidence; medical research; patient selection; pregnancy; proportional hazards model; public health; sexual behavior; South Africa; Adolescent; Biomedical Research; Clinical Trials as Topic; Feasibility Studies; Female; Follow-Up Studies; HIV Infections; HIV Seroprevalence; Humans; Incidence; Patient Selection; Pregnancy; Proportional Hazards Models; Public Health; Sexual Behavior; South Africa
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